Researchers at Rochester Medical Center have seen good results in Provigil (brand name for modafinil) improving the negative side effects of chemotherapy that impact cognitive function. Chemo-brain is a term used to describe the foggy, fuzzy thinking and poor memory experienced by some patients after they have undergone chemotherapy.
The research group based their findings on a study of 68 women undergoing chemotherapy for breast cancer. They were treated with Provigil for 8 weeks to combat fatigue. However, the women found they had significant improvement in their ability to concentrate as well as memory and learning.
Provigil is a drug prescribed for excessive daytime sleepiness due to Narcolepsy (which is a problematic sleep condition) and shift-work sleep disorder. Provigil activates the brain in the same way as stimulants like amphetamines and caffeine. Why not just use Adderall or caffeine? Provigil does not have the negative effects on the heart as does Adderall so it is potentially safer.
The study uses a small group of patients and is funded by the drug company who makes Provigil. Despite this, the results are promising. If future studies confirm that Provigil improves cognitive deficits due to chemotherapy, this could significantly improve the quality of life for patients undergoing chemotherapy.
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