Medication discontinuation syndrome can happen when a person stops their medication abruptly. In general, medication should be tapered off slowly with medical supervision. But since we don’t know precisely how slow is slow enough for each individual, sometimes tapering off the medication can still result in some withdrawal symptoms.
Usual withdrawal symptoms are things like fatigue, irritability, diarrhea, headache, anxiety, or feeling like you have the flu. These symptoms typically last a few to several days.
There have been some who have experienced electric shock sensations when stopping Effexor and some other serotonin agents such as Cymbalta, Paxil, etc. This is very unusual, but I’ve heard patients describe it as a “brain shock” that was worsened with movement. In the literature, reports of these symptoms last up to 5 days.
The origin of these sensations is not entirely clear, but thought to be a form of paresthesia (which is the sensation of feeling tingling or creeping on the skin). Paresthesias result from our nerves being activated in a particular area when there is no apparent trigger for the activation – for example, feeling a pinprick on your skin when you haven’t been pricked by a pin.
The electric shocks have been helped by adding back the medication that was discontinued and tapering it more slowly or adding another long acting serotonin agent such as Prozac.
Therefore, stopping medication abruptly is usually not a good idea, especially if you have been taking a particular agent for a long time. It’s best to discuss a tapering schedule with your doctor so that you can have the smoothest transition possible.
K
Hi Dr Marks,
I have been taking 60mg cymbalta for several years now and I get what I call “Body Shocks” within 24 hours from missing my medication.
I came across this article because I was looking for something that explained/described this sensation.
The feeling is almost like dizziness, or a physical uneasiness and is often exacerbated by movement (turning my head, standing up from sitting etc) but doesn’t feel like low BP faintness. Instead its more like that impulse that shocks you awake when you’re almost asleep – that feeling of falling – it feels like an electric current runs all through my body down to my toes – almost like looking over the edge of a large cliff or off the side of a large building. Its always very uncomfortable.
Love to know if you, or anyone reading/commenting has heard of/experienced this.
Thanks